Event-Driven Optimal Feedback Control for Multi-Antenna Beamforming

Transmit beamforming is a simple multi-antenna technique for increasing throughput and the transmission range of a wireless communication system. The required feedback of channel state information (CSI) can potentially result in excessive overhead especially for high mobility or many antennas. This work concerns efficient feedback for transmit beamforming and establishes a new approach of controlling feedback for maximizing net throughput, defined as throughput minus average feedback cost. The feedback controller using a stationary policy turns CSI feedback on/off according to the system state that comprises the channel state and transmit beamformer. Assuming channel isotropy and Markovity, the controller's state reduces to two scalars. This allows the optimal control policy to be efficiently computed using dynamic programming. Consider the perfect feedback channel free of error, where each feedback instant pays a fixed price. The corresponding optimal feedback control policy is proved to be of the threshold type. This result holds regardless of whether the controller's state space is discretized or continuous. Under the threshold-type policy, feedback is performed whenever a state variable indicating the accuracy of transmit CSI is below a threshold, which varies with channel power. The practical finite-rate feedback channel is also considered. The optimal policy for quantized feedback is proved to be also of the threshold type. The effect of CSI quantization is shown to be equivalent to an increment on the feedback price. Moreover, the increment is upper bounded by the expected logarithm of one minus the quantization error. Finally, simulation shows that feedback control increases net throughput of the conventional periodic feedback by up to 0.5 bit/s/Hz without requiring additional bandwidth or antennas.Comment: 29 pages; submitted for publicatio

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability

BACKGROUND: Protein degradation by the ubiquitin system plays a crucial role in numerous cellular signaling pathways. Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in the ubiquitin-dependent degradation pathway. RESULTS: While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found (USP17K, USP17L, USP17M, and USP17N), from human chorionic villi. Expression analysis showed that USP17 transcripts are highly expressed in the heart, liver, and pancreas and are expressed moderately in various human cancerous cell lines. Amino acid sequence analysis revealed that they contain the highly conserved Cys, His, and Asp domains which are responsible for the deubiquitinating activity. Biochemical enzyme assays indicated that they have deubiquitinating activity. Interestingly, the sequence analysis showed that these proteins, with exception of USP17N, contain the putative hyaluronan/RNA binding motifs, and cetylpyridinium chloride (CPC)-precipitation analysis confirmed the association between these proteins and intracellular hyaluronan and RNA. CONCLUSION: Here, we report that the overexpression of these proteins, with exception of USP17N, leads to apoptosis, suggesting that the hyaluronan and RNA binding motifs in these enzymes play an important role in regulating signal transduction involved in cell death

Feedback-Topology Designs for Interference Alignment in MIMO Interference Channels

Interference alignment (IA) is a joint-transmission technique that achieves the capacity of the interference channel for high signal-to-noise ratios (SNRs). Most prior work on IA is based on the impractical assumption that perfect and global channel-state information(CSI) is available at all transmitters. To implement IA, each receiver has to feed back CSI to all interferers, resulting in overwhelming feedback overhead. In particular, the sum feedback rate of each receiver scales quadratically with the number of users even if the quantized CSI is fed back. To substantially suppress feedback overhead, this paper focuses on designing efficient arrangements of feedback links, called feedback topologies, under the IA constraint. For the multiple-input-multiple-output (MIMO) K-user interference channel, we propose the feedback topology that supports sequential CSI exchange (feedback and feedforward) between transmitters and receivers so as to achieve IA progressively. This feedback topology is shown to reduce the network feedback overhead from a cubic function of K to a linear one. To reduce the delay in the sequential CSI exchange, an alternative feedback topology is designed for supporting two-hop feedback via a control station, which also achieves the linear feedback scaling with K. Next, given the proposed feedback topologies, the feedback-bit allocation algorithm is designed for allocating feedback bits by each receiver to different feedback links so as to regulate the residual interference caused by the finite-rate feedback. Simulation results demonstrate that the proposed bit allocation leads to significant throughput gains especially in strong interference environments.Comment: 28 pages; 11 figures ; submitted to IEEE Trans. on Signal Processin

Pre-coder design over two-symbol extension for K-user cyclic interference channels

The authors consider K-user cyclic single-input–single-output (SISO) interference channel (IC) where each receiver is interfered with from only one neighbouring transmitter. In the K-user cyclic SISO IC, K/2 sum degrees of freedom can be achieved when two-symbol extension is applied even without channel state information at the transmitter. They derive an approximation of the ergodic sum rate as a function of pre-coders and propose designs of pre-coders to maximise the ergodic sum rate

Endoscopic Treatment of Intussusception due to Intestinal Tuberculosis

Traditionally, adult intussusception has required a bowel resection because of the malignancy risk. A patient with anorexia, weight loss, and abdominal pain visited our clinic. A physical exam and imaging study revealed no acute peritoneal signs. A colonoscopy for biopsy and bowel reduction was attempted. The tissue sample was consistent with intestinal tuberculosis. We report intestinal tuberculosis complicating intussusception which was treated without surgical intervention

Capacity Analysis of the Clustered Network MIMO with Overlap

In this paper, we analysis the capacity of the clustered network multiple-input multiple-output (MIMO) systems with overlap. We firstly propose a strategy for clustering base stations (BSs) for the analysis tractability. With an assumption of a large number of transmit and receive antennas, an analytical expression of the ergodic capacity using random matrix theorems is derived. In particular, we develop an asymptotic capacity in low signal to noise ratio (SNR) regime. Based on that, we suggest that the number of overlapping degree of freedom (ODOF) is larger than left [B/6] for the sake of the capacity increment, where B refers to the total number of BSs in the multicell network. We show through numerical examples that the analytical results match the simulation results even when the number of antennas is small

Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability

Abstract Background Protein degradation by the ubiquitin system plays a crucial role in numerous cellular signaling pathways. Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in the ubiquitin-dependent degradation pathway. Results While identifying putative ubiquitin specific protease (USP) enzymes that contain a conserved Asp (I) domain in humans, 4 USP17 subfamily members, highly homologous to DUB-3, have been found (USP17K, USP17L, USP17M, and USP17N), from human chorionic villi. Expression analysis showed that USP17 transcripts are highly expressed in the heart, liver, and pancreas and are expressed moderately in various human cancerous cell lines. Amino acid sequence analysis revealed that they contain the highly conserved Cys, His, and Asp domains which are responsible for the deubiquitinating activity. Biochemical enzyme assays indicated that they have deubiquitinating activity. Interestingly, the sequence analysis showed that these proteins, with exception of USP17N, contain the putative hyaluronan/RNA binding motifs, and cetylpyridinium chloride (CPC)-precipitation analysis confirmed the association between these proteins and intracellular hyaluronan and RNA. Conclusion Here, we report that the overexpression of these proteins, with exception of USP17N, leads to apoptosis, suggesting that the hyaluronan and RNA binding motifs in these enzymes play an important role in regulating signal transduction involved in cell death.</p

Efficient Feedback Design for Interference Alignment in MIMO Interference Channel

Interference alignment (IA) is a joint-transmission technique that achieves the capacity of the interference channel for high signal-to-noise ratios (SNRs). However, most prior works on IA are based on the impractical assumption that perfect and global channel-state information(CSI) is available at all transmitters, resulting in overwhelming feedback overhead. To substantially suppress the feedback overhead, this paper proposes an efficient design of the feedback framework for IA in the K-user multiple-input multiple-output (MIMO) interference channel. The proposed feedback topology supports sequential CSI exchange (feedback and feedforward) between transmitters and receivers and reduces the feedback overhead from a cubic function of K to a linear one, compared to conventional feedback approaches. Given the proposed feedback topology, we consider the limited feedback channel from the receivers to corresponding interferers and analyze the effect of quantization error which generates the residual interference. Also, an efficient feedback-bit allocation algorithm that minimizes the upper-bound of sum residual interference is proposed